| α-卤代桂皮酰胺类化合物的UV,1H NMR及构型研究 |
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| 引用本文： | 王书玉,王动,乔梁,王映芬,庞吉海,刘维勤,李仁利. α-卤代桂皮酰胺类化合物的UV,1H NMR及构型研究[J]. 波谱学杂志, 1987, 4(4): 355-363 |
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| 作者姓名： | 王书玉 王动 乔梁 王映芬 庞吉海 刘维勤 李仁利 |
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| 作者单位： | 北京医科大学药学院 波谱室 |
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| 基金项目： | 中国科学院科学基金资助课题，国家医药管理局资助 |
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| 摘 要： | 本文报道了12对芳环取代的-α-卤代桂皮酰胺类化合物的UV及1H NMR。并通过λmax和1H NMR谱中酰胺氮上的氢及双键β-烯氢的化学位移判断它们的构型,这种判断结果已为X光衍射确证。
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| 关 键 词： | α-卤代桂皮酰胺类化合物 UV 1H NMR 构型 |
| 收稿时间： | 1987-02-09 |
THE STUDY ON UV,1H NMR AND CONFIGURATION OF α-HALOCINNAMAMIDES |
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| Wang Shuyu Wang Dong Qiao Liang Wang Yingfen Pang Jihai Liu Weichin and Li Renli. THE STUDY ON UV,1H NMR AND CONFIGURATION OF α-HALOCINNAMAMIDES[J]. Chinese Journal of Magnetic Resonance, 1987, 4(4): 355-363 |
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| Authors: | Wang Shuyu Wang Dong Qiao Liang Wang Yingfen Pang Jihai Liu Weichin and Li Renli |
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| Affiliation: | Beijing Medical University |
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| Abstract: | UV and 1H NMR of twelve pairs of α-halocinnamamides substituted by aromatic ring are reported. A structure-activity relationship study of a series of(Z) and(E)-N-alkyl-α-halocinnamamides showed that geometrical isomers act differently in the anticonvulsant activty; generally, (Z) derivatives are several times more potent than (E) isomers in the anticonvulsant activity. Their configurations were assigned by their UV γmax and 1H chemical shifts of protons on the amide group and olefinic bond. The configuration was confirmed by the X-ray diffraction results of one pair of these geometric isomers. |
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| Keywords: | α-Halocinnamamides UV 1H NMR configuration |
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