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A photochemical route for efficient cyclopeptide formation with a minimum of protection and activation chemistry
Authors:Griesbeck Axel G  Heinrich Thomas  Oelgemöller Michael  Lex Johann  Molis Arne
Institution:Institute of Organic Chemistry, University of Cologne, Greinstrasse 4, D-50939 K?ln, Germany. griesbeck@unikoeln.de
Abstract:An elaborated protocol is described which allows the efficient transformation of di-, tri-, and tetrapeptides into cyclopeptides with a minimum of protection and activation chemistry using the photoinduced electron transfer initiated decarboxylation of N-phthaloyl peptides resulting in C-C coupling between the initially formed carbon radicals.
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