Electro-responsive transdermal drug delivery behavior of PVA/PAA/MWCNT nanofibers |
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Authors: | Jumi Yun Ji Sun Im Young-Seak Lee Hyung-Il Kim [Author vitae] |
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Institution: | Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University, Daejeon 305-764, Republic of Korea |
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Abstract: | The electro-responsive transdermal drug delivery system was prepared by electrospinning of poly(vinyl alcohol)/poly(acrylic acid)/multi-walled carbon nanotubes (MWCNTs) nanocomposites. The surface modification of MWCNTs was carried out by oxyfluorination to introduce the functional groups on the hydrophobic MWCNTs. The dispersion of MWCNTs and the compatibility with polymer matrices were improved by oxyfluorination. The MWCNT content and oxyfluorination condition played important roles in the swelling and drug release characteristics of nanofibers. The conductivity of nanofibers increased by increasing the content of MWCNTs and performing oxyfluorination with higher oxygen content. Uniform distribution of the oxyfluorinated MWCNTs in the nanofibers was crucial to the electro-responsive swelling and drug releasing behaviors of nanofibers. |
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Keywords: | Transdermal drug delivery system Electro-responsive Multi-walled carbon nanotubes Oxyfluorination Dispersion stability |
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