An auxiliary induced asymmetric synthesis of functionalized cyclobutanes by means of catalytic (2+2)-cycloaddition reaction |
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| Authors: | Kiyosei Takasu |
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| Affiliation: | Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980-8578, Japan |
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| Abstract: | A new entry to optically active hydroxycyclobutanes is described. Treatment of silyl enol ether and (−)-8-phenylmenthyl acrylate in the presence of a catalytic amount of EtAlCl2 affords enantiomerically enriched multi-substituted cyclobutane compounds in a good yield and diastereofacial selectivity. |
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| Keywords: | Hydroxycyclobutanes (2+2)-Cycloadditions Stereoselectivity Chiral auxiliary Asymmetric induction |
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