Ring-opening reaction of methylenecyclopropanes with LiCl, LiBr or NaI in acetic acid |
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| Authors: | Jin-Wen Huang |
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| Institution: | State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China |
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| Abstract: | The methylenecyclopropanes 1 react with LiCl, LiBr or NaI at 80 °C to give the corresponding gem-disubstituted homoallylic halides 2 in good to excellent yields in acetic acid. In some cases, the ring-opening reaction can be completed within 5 min to give the corresponding gem-disubstituted homoallylic halides in high yields. |
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| Keywords: | Methylenecyclopropanes LiCl LiBr NaI gem-Disubstituted homoallylic halides Ring-opening reaction Acetic acid |
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