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Inhibitors of biotin biosynthesis as potential herbicides |
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| Authors: | Ayelet Nudelman Abraham Nudelman Dennis Flint |
| Institution: | a QBI Enterprises Ltd., Weizmann Science Park, Ness Ziona 70400, Israel b Department of Organic Chemistry, Israel Institute for Biological Research, PO Box 19, Ness Ziona 74100, Israel c Department of Chemistry, Bar Ilan University, Ramat Gan 52900, Israel d E. I. Du Pont de Nemours and Company, Central Research and Development, Experimental Station, Wilmington, DE 19880-0328, USA e E. I. Du Pont de Nemours and Company, Stine-Haskell Research Center, Newark, DE 19714, USA |
| Abstract: | Isosteric derivatives and analogues of the 7-keto-8-aminopelargonic acid (KAPA), 7,8-diaminopelargonic acid (DAPA) and desthiobiotin (DTB) vitamer intermediates involved in the biosynthetic pathway of biotin were prepared and evaluated as potential herbicides. The most active compound was desmethyl-KAPA which displayed a GR50 (concentration of the active compound that causes a 50% growth inhibition) value of 8 ppm, where values <50 ppm are considered herbicidal. Other KAPA analogs where the terminal Me group was replaced by bulkier substituents such as Et, i-Pr and HOCH2 showed moderate activity. |
| Keywords: | Biotin Biotin vitamers 7-Keto-8-aminopelerginic acid (KAPA) 7 8-Diaminopelargonic acid (DAPA) Desthiobiotin (DTB) Herbicides Enzyme inhibitors |
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