Synthesis of dibenzofuran-1,4-diones using the Dötz benzannulation |
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Authors: | James C Anderson |
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Institution: | School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK |
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Abstract: | The chromium Fischer carbene complexes of benzofuran and benzothiophene have been prepared and can be used in Dötz benzannulations with alkynes for the regioselective and converg ent synthesis of dibenzofuran-1,4-dione heterocycles. The use of alkynylboronates led to model systems of the tricyclic ring system of popolohuanone E after oxidation. It would appear that the combination of alkynyl boronates with furan type Fischer carbene complexes leads to substantial amounts (∼50%) of protodeboronated products. |
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Keywords: | Dibenzofuran-1 4-diones Chromium carbenes Dö tz benzannulation Alkynyl boronates Popolohuanone E |
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