Amaryllidaceae Alkaloids from Lycoris radiata |
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| Authors: | Tao Feng Yuan‐Yuan Wang Jia Su Yan Li Xiang‐Hai Cai Xiao‐Dong Luo |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650204, P.?R. China, (phone: +86‐871‐5223177;2. fax: +86‐871‐5150227) |
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| Abstract: | A phytochemical investigation on bulbs of Lycoris radiata resulted in the isolation of three new Amaryllidaceae alkaloids, named 5,6‐dehydrodihydrolycorine ( 1 ), 6β‐acetoxycrinamine ( 2 ), and (+)‐8‐O‐acetylhomolycorine α‐N‐oxide ( 3 ), together with eleven known alkaloids, 4 – 14 . The structures of the new alkaloids were established by means of spectroscopic methods, and the known compounds were identified by comparison of their data with those in the literature. Compound 2 showed cytotoxicity against HL‐60, A‐549, and MCF‐7 cells, with IC50 values of 8.1, 24.3, and 15.0 μM , respectively. |
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| Keywords: | Lycoris radiata Alkaloids Amaryllidaceae alkaloids |
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