Three New Triterpenes from Xylarialean sp. A45, an Endophytic Fungus from Annona squamosa L. |
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| Authors: | Ting Lin Xiao Lin Chun‐Hua Lu Yue‐Mao Shen |
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| Affiliation: | 1. The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering;2. Xiamen Engineering Research Center of Marine Microbial Drug Discovery;3. Fujian Laboratory of Pharmaceutical Engineering;4. School of Life Sciences, Xiamen University, No. 422 South Siming Road, Xiamen, Fujian 361005, P.?R. China, (phone: +86‐592‐2184180;5. fax: +86‐592‐2181722) |
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| Abstract: | ![]()
From the fermentation extract of Xylarialean sp. A45, an endophytic fungus of Annona squamosa L., three new triterpenes, namely xylariacins A–C ( 1 – 3 , resp.) were obtained. Their structures were determined by spectroscopic analyses, including 1D‐ and 2D‐NMR experiments and HR‐ESI‐Q‐TOF mass spectrometry. The in vitro cytotoxic activities of compounds 1 – 3 were tested against human tumor cell line HepG2, and these compounds showed modest cytotoxic activity. |
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| Keywords: | Xylarialean sp. A45 Annona squamosa Triterpenes Xylariacins A – C Cytotoxic activity |
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