A practical multigram-scale method for the green synthesis of 5-substituted-1H-tetrazoles in deep eutectic solvent |
| |
| Authors: | Xingquan Xiong Chao Yi Xu Liao Shilin Lai |
| |
| Institution: | College of Materials Science and Engineering, University of Huaqiao, Xiamen 361021, China |
| |
| Abstract: | A series of 5-substituted-1H-tetrazoles have been efficiently synthesized in moderate to excellent yields (68–90%) under mild reaction conditions by combining aryl aldehydes, hydroxylamine hydrochloride with sodium azide in the presence of catalytic amount of Cu(OAc)2 in deep eutectic solvent (DES). The new synthetic method has many advantages, such as high conversion, green reaction medium, easy work-up, low cost, and environment friendly. |
| |
| Keywords: | Aldehydes One-pot synthesis Deep eutectic solvent Green chemistry |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
