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Dopamine Sensor Based on a Composite of Silver Nanoparticles Implemented in the Electroactive Matrix of Calixarenes |
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| Authors: | Gennady A. Evtugyn Rezeda V. Shamagsumova Ruzal R. Sitdikov Ivan I. Stoikov Igor S. Antipin Marina V. Ageeva Tibor Hianik |
| Affiliation: | 1. A.?M. Butlerov' Chemistry Institute, Kazan Federal University, 18 Kremlevskaya Street, Kazan, 420008, Russian Federation;2. Department of Nuclear Physics and Biophysics, Comenius University, Mlynska dolina F1, 842?48 Bratislava, Slovakia;3. Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Lobachevsky Street, 2/31, PO Box 30, Kazan, 420111, Russian Federation |
| Abstract: | A sensitive electrochemical sensor based on a composite containing silver nanoparticles and a redox active thiacalixarene with catechol fragments in the substituents at the lower rim has been developed and used for dopamine detection. The electrochemical investigation of thiacalixarene in homogeneous solution and on the electrode interface showed the reversible character of the redox conversion of catechol fragments and its involvement in the chemical reduction of silver which resulted in formation of uniform nanoparticles of 4–6 nm in diameter. The use of such a material for electrode modification made it possible to record a high amplitude cathodic signal at ?700 mV that was proportional to the dopamine concentration within 1 nM–1 µM. (limit of detection 0.5 nM). |
| Keywords: | Dopamine detection Silver nanoparticles Thiacalixarene Amperometric sensor |