Synthesis of a Novel Series of 2,3‐Disubstituted Quinazolin‐4(3H)‐ones as a Product of a Nucleophilic Attack at C(2) of the Corresponding 4H‐3,1‐Benzoxazin‐4‐one |
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| Authors: | Mahr A. El‐Hashash Yaser A. El‐Badry |
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| Affiliation: | 1. Department of Organic Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt;2. Organic Chemistry Lab., Faculty of Pharmacy, Ain Shams University, 11566 Abbasseya, Cairo, Egypt |
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| Abstract: | A new series of 2,3‐disubstituted quinazolin‐4(3H)‐one derivatives was synthesized by nucleophilic attack at C(2) of the corresponding key starting material 2‐propyl‐4H‐3,1‐benzoxazin‐4‐one (Scheme 2). The reaction proceeded via amidinium salt formation (Scheme 3) rather than via an N‐acylanthranilimide. The structure of the prepared compounds were elucidated by physical and spectral data like FT‐IR, 1H‐NMR, and mass spectroscopy. |
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| Keywords: | Quinazolin‐4(3H)‐one Ring opening 4H‐3,1‐Benzoxazin‐4‐one |
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