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Asymmetric Total Synthesis of Stagonolide G |
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| Authors: | Dasari Ramesh Singanaboina Rajaram Peddikotla Prabhakar Udugu Ramulu Dorigondla Kumar Reddy Yenamandra Venkateswarlu |
| Institution: | 1. Natural Products Laboratory, Organic Chemistry Division‐I, Indian Institute of Chemical Technology, Hyderabad‐500?007, India , (phone: +91‐40‐27193167;2. fax: +91‐40‐27160512) |
| Abstract: | A simple asymmetric total synthesis of stagonolide G ( 1 ) is described. Asymmetric dihydroxylation, regioselective epoxide ring opening, and vinyl Grignard reactions are involved in generating the stereogenic centers C(4) and C(8), followed by Grubbs‐II‐catalyzed ring‐closing metathesis (RCM). |
| Keywords: | Dihydroxylation Epoxide opening Grignard reaction Ring‐closing methathesis Stagonolide G |