A Different Role of Meldrum's Acid in the Biginelli Reaction |
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| Authors: | Jan Svĕtlík Lucia Veizerová |
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| Affiliation: | Department of Pharmaceutical Analysis and Nuclear Pharmacy, Comenius University, Odbojarov 10, SK‐832?32 Bratislava |
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| Abstract: | A Biginelli‐type condensation using Meldrum's acid has been accomplished in refluxing AcOH to give 6‐substituted dihydropyrimidine‐2,4‐(1H,3H)‐diones. In contrast to other aldehydes, the three‐component reaction with salicylaldehyde led to an oxygen‐bridged pyridine. A reaction mechanism is proposed. |
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| Keywords: | Biginelli reaction Meldrum's acid Salicylaldehyde Multicomponent reaction Pyridine, oxygen‐bridged |
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