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Synthesis of Functionalized Thiophenes by Four‐component Reactions of 1,3‐Thiazolidinedione,Aromatic Aldehydes,Cyanoacetamide and Cyclic Secondary Amines
Authors:Rong Yao  Eryan Xia  Jing Sun  Chaoguo Yan
Affiliation:College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China
Abstract:The polysubstituted thiophene derivatives were conveniently prepared by the four‐component reactions of 1,3‐thiazolidinedione, aromatic aldehydes, cyanoacetamide and cyclic secondary amines such as pyrrolidine, morpholine and piperidine. The reaction mechanism is believed to involve domino reactions of Knoevenagel condensation, Michael addition, ring‐opening and recyclization of 1,3‐thiazolidinedione.
Keywords:multicomponent reaction  domino reaction  thiophene  cyanoacetamide  1,3‐thiazolidinedione
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