Two New Sesquiterpenes from Inula salsoloides and Their Inhibitory Activities against NO Production |
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| Authors: | Xiao‐Jia Hu Hui‐Zi Jin Xiao‐Hua Liu Wei‐Dong Zhang |
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| Institution: | 1. School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P.?R. China, (phone: +86‐21‐34205989;2. fax: +86‐21‐34205989);3. School of Medicine of Shanghai Jiao Tong University, Shanghai 200240, P.?R. China;4. Department of Phytochemistry, Second Military Medical University, Shanghai 200433, P.?R. China |
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| Abstract: | Two new sesquiterpenes, inulasalene ( 1 ) and inulasalsolide B ( 2 ), as well as 22 known compounds were isolated from the aerial parts of Inula salsoloides. The structures of the new sesquiterpenes were determined on the basis of their spectroscopic data and chemical properties. Compounds 1 – 4 exhibited potent inhibitory activities against NO production with IC50 values range of 0.010–1.290 μg/ml in lipopolysaccharide (LPS)‐stimulated RAW264.7 cells. |
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| Keywords: | Inula salsoloides Inulasalene Inulasalsolide B Sesquiterpenes Inhibitors |
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