Nine New Norlabdane Diterpenoids from the Leaves of Austroeupatorium inulifolium |
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| Authors: | Yoshinori Saito Sachie Matsuo Suyatno Sutoyo Motoo Tori |
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| Institution: | 1. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro‐cho, Tokushima, 770‐8514 Japan (phone: +81‐88‐602‐8462;2. fax: +81‐88‐655‐3051);3. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, Jl. Ketintang Surabaya, Indonesia |
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| Abstract: | Nine new norlabdane diterpenoids were isolated from the leaves of Austroeupatorium inulifolium collected in Indonesia. All of them have an acyl‐furan unit connected to C(11), and oxygenated functions at C(2) and C(3). The structure elucidations and the assignment of the absolute configurations of the isolated natural products were carried out by extensive spectroscopic analysis and the extended Mosher method, as well as chemical correlations. Antimicrobial activities and cytotoxicity against HL‐60 cells were determined using bioassays. |
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| Keywords: | Austroeupatorium inulifolium Diterpenoids Norlabdane diterpenoids Antimicrobial activity Cytotoxic activity |
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