Rate Acceleration of the Baylis‐Hillman Reaction within Microreactors |
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| Authors: | Jun Yang Li Qi Juan Qiao Yi Chen Huimin Ma |
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| Institution: | 1. Beijing National Laboratory for Molecular Sciences;2. Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;3. Graduate School, Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Based on microreactors, the representative Baylis‐Hillman reaction of cyclopent‐2‐enone coupled with 4‐nitrobenzaldehyde in the presence of imidazole could be accelerated by manipulating the temperature and electric field. Furthermore, the electric field was used in promoting Baylis‐Hillman reaction for the first time with the rate acceleration approximately 5.2‐fold higher than that carried out in conventional vessels as well as 4.0‐fold under control of temperature. Meanwhile, the products of Baylis‐Hillman reaction at every time point could be collected and then determined by capillary micellar electrokinetic chromatography. |
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| Keywords: | microreactor reaction rate acceleration Baylis‐Hillman reaction |
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