Seven New Lignan Esters from Kadsura philippinensis |
| |
| Authors: | Yuan‐Bin Cheng Yu‐Chi Lin Ashraf Taha Khalil Shorong‐Shii Liou Guo‐Chi Lee Yao‐Haur Kuo Ya‐Ching Shen |
| |
| Affiliation: | 1. School of Pharmacy, College of Medicine, National Taiwan University, Jen‐Ai Rd. Sec.?1, Taipei 100, Taiwan (phone: +886‐2‐23123456 ext 62226;2. fax: +886‐2‐23919098);3. Department of Pharmacy, Tajen University, Ping‐Tung, Taiwan;4. Department of Science and Technology, Council of Agriculture Executive Yuan, Taipei, Taiwan;5. National Research Institute of Chinese Medicine, Taipei, Taiwan |
| |
| Abstract: | Five new oxygenated lignans with a dibenzocyclooctadiene skeleton, kadsuphilols P–T ( 1 – 5 ), and two new C19 homolignans, kadsuphilols U and V ( 6 and 7 ), were isolated by chromatographic fractionation of an AcOEt extract of the stems of Kadsura philippinensis. The structures of the isolated metabolites were elucidated through extensive spectroscopic analysis including HR‐ESI‐MS and 2D‐NMR (HMQC, COSY, and HMBC). The configuration at the chiral centers and at the biphenyl moiety were determined by interpretation of NOESY and CD data, respectively. |
| |
| Keywords: | Kadsura philippinensis Lignans Dibenzocyclooctadienes Kadsuphilols P – V Homolignans |
|
|
