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Cover Picture: Studies of Glutathione Transferase P1‐1 Bound to a Platinum(IV)‐Based Anticancer Compound Reveal the Molecular Basis of Its Activation (Chem. Eur. J. 28/2011)
Authors:Lorien J. Parker  Louis C. Italiano  Craig J. Morton  Nancy C. Hancock  David B. Ascher  Jade B. Aitken  Hugh H. Harris  Pablo Campomanes  Ursula Rothlisberger  Anastasia De Luca  Mario Lo Bello  Wee Han Ang  Paul J. Dyson  Michael W. Parker
Affiliation:1. Biota Structural Biology Laboratory, St. Vincent's Institute of Medical Research, 41 Victoria Parade, Fitzroy, Victoria 3065 (Australia), Fax: (+61)?3‐9416‐2676;2. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 (Australia);3. School of Chemistry, The University of Sydney, New South Wales 2006 (Australia);4. School of Chemistry and Physics, University of Adelaide, South Australia 5005 (Australia);5. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland);6. Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, Rome 00133 (Italy);7. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore)
Abstract:
Keywords:antitumor agents  detoxification  ethacrynic acid  glutathione transferases  X‐ray crystallography
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