neo‐Clerodane Diterpenoids from the Aerial Part of Scutellaria barbata |
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| Authors: | Hanna Lee Sang Hee?Shim |
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| Institution: | 1. School of Biotechnology, Yeungnam University, 214‐1 Dae‐dong, Gyeongsan, Gyeongbuk 712‐749, South Korea (phone: +82‐53‐810?3028;2. fax: +82‐53‐810?4769) |
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| Abstract: | Three new neo‐clerodane diterpenoids, barbatellarines C–E ( 1 – 3 ), were isolated from the CHCl3‐soluble fraction of the aerial part of Scutellaria barbata. Their chemical structures were elucidated by detailed analysis of NMR and MS data. Compounds 1 and 2 were C(13) epimers, which was confirmed by an NOE difference experiment and the NOESY spectrum. The relative configuration was determined on the basis of the 1H‐NMR J‐value and NOE data, while the absolute configuration of the previously isolated analogue, barbatellarine B ( 4 ), as a representative member of the group, was assigned by CD analysis. |
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| Keywords: | Scutellaria barbata neo‐Clerodane diterpenoids Barbatellarines C – E Diterpenoids |
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