Steric Effect of Carboxylate Ligands on Pd‐Catalyzed Intramolecular C(sp2)–H and C(sp3)–H Arylation Reactions |
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| Authors: | Yutaka Tanji Naoya Mitsutake Prof. Dr. Tetsuaki Fujihara Prof. Dr. Yasushi Tsuji |
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| Affiliation: | Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan |
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| Abstract: | A bulky carboxylic acid bearing three cyclohexylmethyl substituents at the α‐position, namely, tri(cyclohexylmethyl)acetic acid, is demonstrated to act as an efficient ligand source in Pd‐catalyzed intramolecular C(sp2)?H and C(sp3)?H arylation reactions. The reactions proceed smoothly under mild reaction conditions, even at room temperature due to the steric bulk of the carboxylate ligands, which accelerates the rate‐determining C?H bond activation step in the catalytic cycle. |
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| Keywords: | arylation carboxylic acids C− H activation homogeneous catalysis palladium |
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