Synthesis, structure and thermal stability of fully hydrophobic porphyrin-DNA conjugates |
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| Authors: | Takashi Murashima Kazuyuki Hayata Jun Matsui Daisuke Miyoshi Takashi Yamada Naoki Sugimoto |
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| Institution: | a Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan
b Department of Chemistry, Faculty of Science and Engineering, Konan-University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan |
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| Abstract: | The DNAs modified with tetraphenyl porphyrin at the center of 13mer oligonucleotide were synthesized using phosphoramidite chemistry and automated DNA synthesis. When the porphyrin modified oligonucleotide was annealed with its complementary strand, they formed a standard B-form duplex. The porphyrin moiety intercalated in the duplex, and moderately lowered the thermal stability. |
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