Synthetic potential of 2-oxobenzo[h]chromene for the construction of polycyclic azaheteroaromatics with a steroid-like skeleton

An efficient and concise synthesis of 17-amino-6,15-dihydro-7H-11-oxa-15,16-diazacyclopentaa]phenanthren-12-ones has been delineated from the reaction of 4-methylsulfanyl/sec-amino-2-oxo-5,6-dihydro-2H-benzoh]chromene-3-carbonitriles and hydrazine hydrate (98%) at room temperature. Reaction at reflux produced different products, characterized as 1-amino-3b,4,5,11-tetrahydro-3H-2,3,10,11-tetraazanaphtho2,1-e]azulen-12-ones in moderate yields.