Nuclear fluorination of 2,4-diarylthiazoles with Accufluor |
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Authors: | Timmeda F Campbell |
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Institution: | Department of Chemistry, Georgia State University, Atlanta, GA 30303, United States |
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Abstract: | A series of 2,4-diphenylthiazole derivatives were synthesized and directly fluorinated at the 5-position by reaction with the N-F fluorinating reagent Accufluor®. Although fluorination occurred selectively at the thiazole ring, it was always incomplete and thus yields for the novel fluorinated products were low to moderate (19-43%) following purification to remove starting material. Nonetheless, the target compounds were obtained in a convenient and straightforward manner. Selectfluor® was not as effective as Accufluor® as it gave a trace amount of the 5-chlorothiazole that was difficult to remove by chromatography. |
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Keywords: | Thiazole Fluorination Accufluor® Selectfluor® Substituent effects |
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