Preparation of 3-substituted and 2,3-disubstituted-4,4,4-trifluoro-2-butenoic acids—Perkin condensation of activated aromatic ketones |
| |
Authors: | Szabolcs Cserényi |
| |
Institution: | Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged H-6720, Hungary |
| |
Abstract: | The Perkin reaction of the activated aromatic ketones (2,2,2-trifluoroacetophenone and its 4′-phenyl-derivative) with various condensing agents (acetic anhydride, propionic anhydride, phenylacetic acid/acetic anhydride) gives the title compounds in good or moderate yields, and high E-stereoselectivity. For some derivatives an appreciable amount of the Z isomer was also formed. Several of the resulting butenoic acids and their methyl esters are synthesised and characterised for the first time. |
| |
Keywords: | Trifluoro-activated aromatic ketones Perkin condensation Stereoisomers |
本文献已被 ScienceDirect 等数据库收录! |
|