Synthesis and bioactivity of novel (3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl containing acrylate and acrylonitrile derivatives |
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| Authors: | Chun-Rui Yu Long-He Xu Song Tu Bin Li |
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| Institution: | a State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, PR China
b National Pesticide Engineering Research Center, Shenyang Research Institute of Chemical Industry, Shenyang 110021, PR China |
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| Abstract: | Fifteen novel (3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl containing Baylis-Hillman adduct derivatives were designed and synthesized. Evaluation of their biological activities showed that methyl 2-((3-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenoxy)(phenyl)methyl)acrylate (2g) exhibited efficient broad-spectrum fungicidal activity, with 100% control of wheat powdery mildew and cucumber downy mildew and 98% control of cucumber anthracnose at 400 g ai/ha. Some of the other title compounds 2, 3 and two Baylis-Hillman bromide intermediates (11a, 11b) had moderate to good fungicidal activity. |
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| Keywords: | Synthesis Fungicidal activity (3-Chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl Baylis-Hillman adduct |
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