Solution-phase synthesis of alpha-human atrial natriuretic peptide (alpha-hANP) |
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| Authors: | M Yoshida M Shimokura Y Fujiwara T Fujisaki K Akaji Y Kiso |
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| Institution: | Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan. |
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| Abstract: | Alpha-human atrial natriuretic peptide (alpha-hANP) was synthesized by assembling six peptide fragments in solution followed by deprotection with HF and subsequent air-oxidation. The trimethylbenzyl group was employed as an S-protecting group of cysteine. The HF-dimethylselenide-m-cresol system was employed as a final deprotecting reagent and, at the same time, as a reducing reagent of Met(O). Synthetic alpha-hANP elicited potent diuretic and natriuretic activity in rats. |
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