Human in vitro reporter model of neuronal development and early differentiation processes |
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| Authors: | Sebastien Couillard-Despres Eike Quehl Katrin Altendorfer Claudia Karl Sonja Ploetz Ulrich Bogdahn Juergen Winkler Ludwig Aigner |
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| Institution: | 1.Department of Neurology,University of Regensburg,Regensburg,Germany |
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| Abstract: | Background During developmental and adult neurogenesis, doublecortin is an early neuronal marker expressed when neural stem cells assume
a neuronal cell fate. To understand mechanisms involved in early processes of neuronal fate decision, we investigated cell
lines for their capacity to induce expression of doublecortin upon neuronal differentiation and develop in vitro reporter models using doublecortin promoter sequences. |
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