Synthetic Studies Towards Taxol Analogs: Chemoselective Cleavage of C-5 Cinnamoyl Group in Taxane Group of Diterpenoids with Hydroxylamine |
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| Authors: | Yadagiri Bathini Ronald G Micetich Mohsen Daneshtalab |
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| Institution: | SynPhar Laboratories Inc. , #2, 4290-91A Street, Edmonton, Alberta, Canada , T6E 5V2 |
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| Abstract: | Taxane group of diterpenoids 2 and 3 which possess cinnamoyl moiety at C-5 position underwent selective cleavage to C-5 hydroxy compounds 4 and 5 on treatment with hydroxylamine. The resulting compounds were characterised based on their spectral data. |
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