Chlorotrimethylsilane Mediated Formation of ω-Allyl Esters of Aspartic And Glutamic Acids |
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| Authors: | Peter J Belshaw Shadreck Mzengeza Gilles A Lajoie |
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| Institution: | Department of Chemistry , University of Waterloo , Waterloo, Ont., Canada , N2L 3G1 |
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| Abstract: | The protection of the ω-carboxylic function of aspartic and glutamic acids by an allyl ester is advantageous because of its orthogonality with most protecting groups and its compatibility with a number of reagents. In this communication we describe a simple method using chlorotrimethylsilane in the presence of allyl alcohol which gives exclusively the ω-allyl esters of both aspartic and glutamic acids in excellent yield. |
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