Synthetic Approaches to 2-Pyrrolidinone-5-carboxaldehyde |
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| Authors: | Jeffrey Deskus Michael B Smith Tiberiu Simandan |
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| Institution: | Department of Chemistry , University of Connecticut , Storrs, Room 151, 215 Glenbrook Road, Connecticut , 06269-3060 |
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| Abstract: | We have examined routes for the preparation of 2-pyrrolidinone-5S-carboxaldehyde which include oxidation of 5-hydroxymethyl-2-pyrrolidinone and reduction of 5-oxoproline ethyl ester. Only the oxidation route proved satisfactory. Moffatt oxidation was most efficient but PCC oxidation gave modest yields of the desired aldehyde. |
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