A Very Short and Efficient Total Synthesis of Otanthus Maritima Amide. |
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| Authors: | Moncef Bellassoued Malika Salemkour Emmanuelle Reboul |
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| Institution: | Laboratoire de Synthèse Organométallique associé au CNRS, Université Pierre et Marie Curie , Tour 44-45, 1er étage, 4 place Jussieu, 75252, Paris, Cedex 05, France |
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| Abstract: | A new total synthesis of Otanthus Maritima amide 1 was achieved from 6-trimetylsily N-tert-butyl sorbaldimine 6 in 76% global yield. The natural product 1 was obtained in three steps by condensation of 6 on thiophenal in the presence of catalytic amount of CsF (10%) in DMSO followed by oxidation and amidification of the corresponding intermediate. |
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