An Efficient Synthesis of Racemic and Optically Active Telluromethionine |
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| Authors: | Louis A. Silks III Jeffrey O. Boles Brenna P. Modi R. Bruce Dunlap Jerome D. Odom |
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| Affiliation: | Department of Chemistry , University of South Carolina , Columbia , South Carolina , 29208 , USA |
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| Abstract: | A direct and efficient route for the construction of racemic and optically active L-telluromethionine (L-Te-Met) starting from the readily available hydrochloride salt of α-amino-γ-butyrolactone and lithium methyltellurolate is described. The reaction has been successfully scaled up to afford gram quantities of L-Te-Met in 75–80% yield. |
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