Potassium Fluoride Promoted Reaction of 3-Acylsubsti-Tuted 2H-1-Benzopyran-2-Ones with Acid Anhydrides. An Improved Method for the Synthesis of 4-(2-Oxoalkyl)-2H-Chroman-2-Ones. Part III1 |
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| Authors: | Anka Bojilova Nestor A. Rodics Rozitsa Nikolova Christo Ivanov |
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| Affiliation: | 1. Department of Chemistry , University of Sofia , Anton Ivanov 1, 1126, Sofia, Bulgaria;2. Laboratory of Organic Chemistry , University of Thessaloniki , Thessaloniki, Greece |
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| Abstract: | The reaction of 3-acylsubstituted 2H-1-benzo-pyran-2-ones 1, 5 and 11a-c with acid anhydrides in the presence of potassium fluoride (KF)/molecular sieves 4A gives the 4-(2-oxoalkyl)-2-oxochromans 2, 6 and 12a-c as the main products. Also the 3-carboxylic acid derivatives, such as esters and N,N-dialkylamides, of 2H-1-benzopyran-2-one (11d-g) react with isobutyric acid anhydride in the presence of KF/molecular sieves 4A to give the corresponding 2-oxochroman-4-acetic acid derivatives. |
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| Keywords: | Melatonin Microwave assisted organic synthesis Phase-transfer catalytic condensation |
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