Observations on the Hantzsch Reaction: Synthesis of N-tBoc-S-Dolaphenine |
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| Authors: | Martin W. Bredenkamp Cedric W. Holzapfel Renske M. Snyman Wynand J. van Zyl |
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| Affiliation: | Department of Chemistry and Biochemistry , Rand Afrikaans University , P. O. Box 524, Aucklandpark , 2006 , Johannesburg , South Africa |
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| Abstract: | An understanding of the mechanism by which racemization occurs in the Hantzsch reaction preparation of 2-(1-aminoalkyl)thiazoles has enabled the development of a methodology to prevent racemization. N-tBoc-S-dolaphenine (3) is then synthesized using this methodology. |
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