A Facile Route to 9-Phosphorylated Neuraminic Acid Derivatives |
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| Authors: | Marcos CaroliRezende Silvia SepúlvedaBoza |
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| Affiliation: | 1. Facultad de Química y Biologia , Universidad de Santiago de Chile , Av. B.O'Higgins, Santiago, 3363, Chile;2. Facultad de Ciencias Médicas , Universidad de Santiago de Chile , Av. B.O'Higgins, Santiago, 3363, Chile |
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| Abstract: | ![]()
The phosphitylation of 2-α-O-Benzyl-N-acetylneuraminic acid (2) and of the methyl 2-α-O-methyl-N-acetylneuraminate (3) with 2-chloro-4H-1,2,3-benzodioxaphosphorin-4-one (4) is described. The reaction affords a ready access to 9-phosphorylated derivatives of N-acetylneuraminic acid (1). |
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