A Diastereoselective Preparation of 7-Ethyl-7-methylbicyclo[3.2.0]HEPT-2-en-6-one(1) |
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| Authors: | Timothy E Glass Susan J Klein Phyllis A Leber |
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| Institution: | Department of Chemistry , Franklin and Marshall College , Lancaster, PA, 17604 |
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| Abstract: | Alkylation of 7-endo-ethylbicyclo3.2.0]hept-2-en-6-one (2a) and 7-endo-methylbicyclo3.2.0]hept-2-en-6-one (2b) with lithium diisopropylamide (LDA) and the appropriate alkyl iodide (methyl and ethyl iodide, respectively) afforded the title compound such that alkylation had occurred exclusively on the exo face of the bicyclo3.2.0] system. |
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