Syntheses of 3-Chloro-7-[(Chlorocarbonyl)Methoxy]-4-Methylcoumarin |
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| Authors: | Lawrence R. Phillips Jeffrey G. Supko Tracy L. Wolfe Louis Malspeis |
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| Affiliation: | Laboratory of Pharmaceutical Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment , National Cancer Institute , Frederick, Maryland , 21702-1201 |
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| Abstract: | Two efficient syntheses of 3-chloro-7-[(chlorocarbonyl)methoxy]-4-methylcoumarin are described, one utilizing traditional chemistry starting from 3-chloro-7-hydroxy-4-methylcoumarin, while the other uses a novel reagent, sulfuryl chloride/thionyl chloride, in a one-pot reaction starting from 7-(carboxymethoxy)-4-methylcoumarin. |
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