Synthesis of 2-Acyl- and 2-Sulfonylbenzisoselenazol-3(2H)-ones |
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Authors: | Sungano Mhizha Jacek Młochowski |
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Institution: | Institute of Organic Chemistry , Biochemistry and Biotechnology, Technical University , 50 370, Wroc?aw, Poland |
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Abstract: | Synthesis of two new groups of organoselenium compounds: 2-acyl-and sulfonylbenzisoselenazol-3(2H)-ones (3, 4), potential immunostimulants, in two alternative ways was elaborated. One of them was based on the reaction of 2-chlorobenzoyl chloride (2) with primary amides while the second one involved N-acylation or N-sulfonylation of benzisoselenazol-3(2H)-one (5) with acid chlorides. Two exceptions from general reaction of dichloride 2 with amides were observed. Thioacetamide produced 2,1-benzothiaselenophenone (6), and urea gave 6,7-benzo-2,4-diaza-1-selenacyclohepta-3,5-dione (7). |
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