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A convenient One-Pot Synthesis of an Unsymmetrical Propane-1,3-diamine BRL 61010A |
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| Authors: | Robin P Attrill Thomas W Ramsay Graham R Slater Paul Smith |
| Institution: | Synthetic Chemistry SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue , Harlow, Essex, CM19 5AW |
| Abstract: | The one-pot condensation of N-methylhomoveratrylamine with acrolein followed by in situ reductive amination with 3,4-dimethoxyaniline to give an unsymmetrical propane 1,3-diamine in excellent yield is described. |
| Keywords: | Water-soluble phosphine Aqueous phase catalysis Allylic isomerization |