|
|||||
|
|
| 天然环酯肽Obyanamide的全合成 | |
| 引用本文： | 王晓季,李阳,陈立功,郑鹏武,段学民,许正双.天然环酯肽Obyanamide的全合成[J].有机化学,2007,27(8):1007-1012. |
| 作者姓名： | 王晓季 李阳 陈立功 郑鹏武 段学民 许正双 |
| 作者单位： | 1. 江西科技师范学院药学院,南昌,330013 2. 天津大学化工学院,天津,300072 3. 北京大学深圳研究生院化学基因实验室,深圳,518055 |
| 基金项目： | 江西省教育厅(Nos．赣教技字[2007]282号和赣教技字[2006]301号)资助项目． |
| 摘 要： | 针对目标化合物Obyanamide的结构特征, 运用反合成设计, 将其切为四个合成片断: N-甲基缬氨酸-N-甲基苯丙氨酸二肽(片断A)、噻唑酸衍生物(片断B)、L-乳酸衍生物(片断C)和β-氨基戊酸衍生物(片断D), 并对各个合成片断进行了合成, 最终顺利完成了对天然海洋环酯肽Obyanamide的全合成. 其化学结构经1H NMR, 13C NMR, HMBC以及HRMS (FAB)予以确证. |
| 关 键 词： | Obyanamide 全合成 天然环酯肽 |
| 收稿时间： | 2006-8-1 |
| 修稿时间： | 2006-08-012007-03-14 |
Total Synthesis of Natural Cyclic Depsipeptide-Obyanamide |
|
| WANG,Xiao-Ji,LI,Yang,CHEN,Li-Gong,ZHENG,Peng-Wu,DUAN,Xue-Min,XU,Zheng-Shuang.Total Synthesis of Natural Cyclic Depsipeptide-Obyanamide[J].Chinese Journal of Organic Chemistry,2007,27(8):1007-1012. | |
| Authors: | WANG Xiao-Ji LI Yang CHEN Li-Gong ZHENG Peng-Wu DUAN Xue-Min XU Zheng-Shuang |
| Institution: | 1. School of Pharmacy, Jiangxi Science and Technology Normal University, Nanchang 330013; 2. School of Chemical Engineering, Tianjin University, Tianjin 300072; 3. Laboratory of Chemical Genomics, The Shenzhen Graduate School of Peking University, Shenzhen 518055 |
| Abstract: | Based on the structural features of obyanamide,the target molecule was disconnected into four fragments by applying retrosynthetic analysis method,i.e.,N-Me-Phe-N-Me-Val(fragment A),thiazole car- boxy acid derivative(fragment B),lactic acid derivative(fragment C)and unnatural 3-aminopentanoic acid (fragment D).The total synthesis of a natural marine cytotoxic cyclic depsipeptide obyanamide was accomplished successfully from synthesized the fragments A,B,C and D.The structures of the synthesized intermediates and product was identified by ~1H NMR,~(13)C NMR,HMBC and HRMS(FAB)spectra. |
| Keywords: | Obyanamide |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《有机化学》浏览原始摘要信息 | |
| 点击此处可从《有机化学》下载免费的PDF全文 | |