New approach to the synthesis of 2,3-substituted γ-aminobutyric acids and their derivatives |
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| Authors: | D S Tereshchenko Yu V Skornyakov E V Shuvalova E F Litvinov M V Proskurnina N S Zefirov |
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| Institution: | (1) Organic Chemistry Department, Russia;(2) Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninskii pr. 47, Moscow, 119991, Russia |
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| Abstract: | A new approach to the synthesis of 2,3-substituted γ-aminobutyric acids is proposed. This method consists of the selective catalytic reduction of substituted 3-cyanopropanoic acid esters, which are generated in high yield in the reaction of disubstituted cyclopropenes with sodium cyanide in the corresponding alcohol. |
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