G-CSF protects motoneurons against axotomy-induced apoptotic death in neonatal mice |
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Authors: | Alexandre Henriques Claudia Pitzer Luc Dupuis Armin Schneider |
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Affiliation: | (1) SYGNIS Bioscience, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany;(2) University of Strasbourg, Faculty of Medicine, UMRS692, Strasbourg, France;(3) INSERM U692, Strasbourg, France |
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Abstract: |
Background Granulocyte colony stimulating factor (G-CSF) is a growth factor essential for generation of neutrophilic granulocytes. Apart from this hematopoietic function, we have recently uncovered potent neuroprotective and regenerative properties of G-CSF in the central nervous system (CNS). The G-CSF receptor and G-CSF itself are expressed in α motoneurons, G-CSF protects motoneurons, and improves outcome in the SOD1(G93A) transgenic mouse model for amyotrophic lateral sclerosis (ALS). In vitro, G-CSF acts anti-apoptotically on motoneuronal cells. Due to the pleiotrophic effects of G-CSF and the complexity of the SOD1 transgenic ALS models it was however not possible to clearly distinguish between directly mediated anti-apoptotic and indirectly protective effects on motoneurons. Here we studied whether G-CSF is able to protect motoneurons from purely apoptotic cell death induced by a monocausal paradigm, neonatal sciatic nerve axotomy. |
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