| Characterization, Crystal Structure and Initial DNA Binding Interaction of Two Cu（Ⅱ） Complexes with 4,5-Diazafluoren-9-one |
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| 引用本文： | 宋艳虹,张荣兰,孙庆津,许占位,高全昌,刘华强,赵建社.Characterization, Crystal Structure and Initial DNA Binding Interaction of Two Cu（Ⅱ） Complexes with 4,5-Diazafluoren-9-one[J].中国化学,2007,25(10):1508-1513. |
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| 作者姓名： | 宋艳虹 张荣兰 孙庆津 许占位 高全昌 刘华强 赵建社 |
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| 作者单位： | Shaanxi Key Laboratory of Physico-inorganic Chemistry, Department of Chemistry, Northwest University, Xi＇an, Shaanxi 710069, China |
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| 基金项目： | Project supported by the Program for Changjiang Scholars and Innovative Research Team in University, PCSIRT （No. IRT 0559）, the National Natural Science Foundation of China （No. 20671076）, the Major State Basic Research Development Program of China （the 973 Program, No. 2003CB214606）, the Key Laboratory Research and Establishment Program of Shaanxi Education Section （No. 03JS006）, and the Special Foundation of Shaanxi Education Section （No. 04JK143）. |
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| 摘 要： | Two new complexes Cu（dafo）2（en）]（ClO4）2·2H2O （en=NH2CH2CH2NH2） 1 and Cu（dafo）2（dap）]（ClO4）2·2H2O dap=NH2CH2CH（CH3）NH2] 2 （dafo=4,5-diazafluoren-9-one） have been synthesized and characterized by elemental analysis, IR and UV spectra. Meanwhile, the complex 1 has been characterized by single crystal X-ray diffraction analysis. The initial DNA binding interactions of the complexes 1 and 2 have been investigated by UV spectra, emission spectra and cyclic voltammogram. Concluding the results of three methods used to measure the interaction of complexes 1 and 2 with DNA, the action mode of the two complexes with DNA is intercalation, and character of ligands and steric effect may affect the interaction of the complexes with DNA.
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| 关 键 词： | 铜 复合物 晶体结构 特征 DNA 相互作用 |
| 修稿时间： | 2007-02-01 |
Characterization,Crystal Structure and Initial DNA Binding Interaction of Two Cu(II) Complexes with 4,5‐Diazafluoren‐9‐one |
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| SONG, Yan-Hong ZHANG, Rong-Lan SUN, Qing-Jin XU, Zhan-Wei GAO, Quan-Chang LIU, Hua-Qiang ZHAO, Jian-She.Characterization,Crystal Structure and Initial DNA Binding Interaction of Two Cu(II) Complexes with 4,5‐Diazafluoren‐9‐one[J].Chinese Journal of Chemistry,2007,25(10):1508-1513. |
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| Authors: | SONG Yan-Hong ZHANG Rong-Lan SUN Qing-Jin XU Zhan-Wei GAO Quan-Chang LIU Hua-Qiang ZHAO Jian-She |
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| Institution: | 1. Shaanxi Key Laboratory of Physico‐inorganic Chemistry, Department of Chemistry, Northwest University, Xi'an, Shaanxi 710069, China;2. Tel.: 0086‐13096987598 |
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| Abstract: | Two new complexes Cu(dafo)2(en)](ClO4)2·2H2O (en=NH2CH2CH2NH2) 1 and Cu(dafo)2(dap)](ClO4)2· 2H2O dap=NH2CH2CH(CH3)NH2] 2 (dafo=4,5‐diazafluoren‐9‐one) have been synthesized and characterized by elemental analysis, IR and UV spectra. Meanwhile, the complex 1 has been characterized by single crystal X‐ray diffraction analysis. The initial DNA binding interactions of the complexes 1 and 2 have been investigated by UV spectra, emission spectra and cyclic voltammogram. Concluding the results of three methods used to measure the interaction of complexes 1 and 2 with DNA, the action mode of the two complexes with DNA is intercalation, and character of ligands and steric effect may affect the interaction of the complexes with DNA. |
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| Keywords: | copper(II) complex crystal structure characterization initial DNA binding interaction |
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