| L-Prolinamide Catalyzed Aqueous Direct Aldol Reaction： an Environment-friendly Method for the Synthesis of β- Hydroxyl keto nes |
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| 引用本文： | 彭以元,刘汉,崔明,程津培.L-Prolinamide Catalyzed Aqueous Direct Aldol Reaction： an Environment-friendly Method for the Synthesis of β- Hydroxyl keto nes[J].中国化学,2007,25(7):962-967. |
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| 作者姓名： | 彭以元 刘汉 崔明 程津培 |
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| 作者单位： | [1]Key Laboratory of Green Chemistry, Jiangxi Province and Department of Chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330027, China [2]Department of Chemistry and State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China [3]Key Laboratory of Poyang Lake Ecological Environment and Resource Development, Jiangxi Normal University, Nanchang, Jiangxi 330027, China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China （Nos. 20342007, 20462003, 20452001 and 20421202）. |
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| 摘 要： | An environment-friendly L-prolinamide catalyzed aldol reaction has been developed. The reaction exhibited broad substrate generality, and high yields with good diastereoselectivity were obtained for cyclic ketones.The simplicity of product isolation, usage of water as environmentally benign reaction medium, and the usage of cheap, readily available and recyclable catalyst make this process promising to be developed for large-scale preparation of β-hydroxyl ketones.
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| 关 键 词： | 丁间醇醛反应 绿化学 脯氨酰胺 环境方法 |
| 修稿时间： | 2006-12-122007-03-19 |
L-Prolinamide Catalyzed Aqueous Direct Aldol Reaction： an Environment-friendly Method for the Synthesis of β- Hydroxyl keto nes |
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| PENG Yi-Yuan, LIU Hana, CUI Ming,CHENG Jin- Pei.L-Prolinamide Catalyzed Aqueous Direct Aldol Reaction： an Environment-friendly Method for the Synthesis of β- Hydroxyl keto nes[J].Chinese Journal of Chemistry,2007,25(7):962-967. |
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| Authors: | PENG Yi-Yuan LIU Hana CUI Ming CHENG Jin- Pei |
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| Institution: | 1. Key Laboratory of Green Chemistry, Jiangxi Province and Department of Chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330027, China ;2. Department of Chemistry and State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China ;3. Key Laboratory of Poyang Lake Ecological Environment and Resource Development, Jiangxi Normal University, Nanchang, Jiangxi 330027, China |
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| Abstract: | An environment‐friendly L‐prolinamide catalyzed aldol reaction has been developed. The reaction exhibited broad substrate generality,and high yields with good diastereoselectivity were obtained for cyclic ketones. The simplicity of product isolation, usage of water as environmentally benign reaction medium, and the usage of cheap, readily available and recyclable catalyst make this process promising to be developed for large‐scale preparation of β‐hydroxyl ketones. |
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| Keywords: | aldol reaction L-prolinamide β-hydroxylketone green chemistry |
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