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| Studies on PNPP Hydrolysis Catalyzed by Schiff Base Cobalt（Ⅱ） Complexes Containing Benzoaza-15-crown-5 | |
| 引用本文： | 胡伟 王莹 李建章 杜娟 孟祥光 胡常伟 曾宪诚. Studies on PNPP Hydrolysis Catalyzed by Schiff Base Cobalt（Ⅱ） Complexes Containing Benzoaza-15-crown-5[J]. 中国化学, 2007, 25(6): 765-771. DOI: 10.1002/cjoc.200790141 |
| 作者姓名： | 胡伟 王莹 李建章 杜娟 孟祥光 胡常伟 曾宪诚 |
| 作者单位： | [1]Department of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China [2]Department of Chemistry, Sichuan University of Science ＆ Engineering, Zigong, Sichuan 643000, China |
| 基金项目： | Project supported by the Educational Department of Sichuan Government （No. 2005D007） and the National Natural Science Foundation of China （Nos. 20173038, 20107004）. |
| 摘 要： | Three novel Schiff base cobalt（Ⅱ） complexes containing benzoaza-15-crown-5, CoL^1, CoL^2 and CoL^3 were synthesized and characterized, and these complexes were used in catalytic hydrolysis of carboxylic ester （PNPP, p-nitrophenyl picolinate） as mimic hydrolytic metalloenzyme. The analysis of specific absorption spectra of the hydrolytic reaction systems indicated that the catalytic hydrolysis involved the key intermediates formed by PNPP with cobalt（Ⅱ） complexes. The CoL^3 bearing the electron withdrawing group shows better catalytic activity due to its stabilization effect on active species MLS^-. The catalytic mechanism of PNPP hydrolysis was also proposed. The kinetic parameter of PNPP catalytic hydrolysis has been calculated and the activation energy for the catalytic hydrolysis is 43.69, 39.76 and 35.44 kJ·mol^-1, respectively. |
| 关 键 词： | 羧酸脂 PNPP 水解 催化 Schiff碱钴配合物 苯并氮杂-15-冠-5 |
| 修稿时间： | 2006-06-222007-02-02 |
Studies on PNPP Hydrolysis Catalyzed by Schiff Base Cobalt（Ⅱ） Complexes Containing Benzoaza-15-crown-5 |
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| HU, Wei WANG, Ying LI, Jian-Zhang DU, Juan MENG, Xiang-Guang HU, Chang-Wei ZENG, Xian-Cheng. Studies on PNPP Hydrolysis Catalyzed by Schiff Base Cobalt（Ⅱ） Complexes Containing Benzoaza-15-crown-5[J]. Chinese Journal of Chemistry, 2007, 25(6): 765-771. DOI: 10.1002/cjoc.200790141 | |
| Authors: | HU Wei WANG Ying LI Jian-Zhang DU Juan MENG Xiang-Guang HU Chang-Wei ZENG Xian-Cheng |
| Affiliation: | HU, Wei WANG, Ying LI, Jian-Zhang DU, Juan MENG, Xiang-Guang HU, Chang-Wei ZENG, Xian-Cheng (a Department of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China; b Department of Chemistry, Sichuan University of Science ＆ Engineering, Zigong, Sichuan 643000, China) |
| Abstract: | Three novel Schiff base cobalt(II) complexes containing benzoaza‐15‐crown‐5, CoL1, CoL2 and CoL3 were synthesized and characterized, and these complexes were used in catalytic hydrolysis of carboxylic ester (PNPP, p‐nitrophenyl picolinate) as mimic hydrolytic metalloenzyme. The analysis of specific absorption spectra of the hydrolytic reaction systems indicated that the catalytic hydrolysis involved the key intermediates formed by PNPP with cobalt(II) complexes. The CoL3 bearing the electron withdrawing group shows better catalytic activity due to its stabilization effect on active species MLS?. The catalytic mechanism of PNPP hydrolysis was also proposed. The kinetic parameter of PNPP catalytic hydrolysis has been calculated and the activation energy for the catalytic hydrolysis is 43.69, 39.76 and 35.44 kJ·mol?1, respectively. |
| Keywords: | crowned Schiff base cobalt（Ⅱ） complex mimic hydrolase catalytic kinetics carboxylic ester hydrolysis |
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