| Catalytic Hydrogenation of α,β-Epoxyketones to β-Hydroxyketones with Two Sulfinyl Analogues of Coenzyme NADH Models |
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| 引用本文： | 谢昆,崔毅,刘有成,傅尧.Catalytic Hydrogenation of α,β-Epoxyketones to β-Hydroxyketones with Two Sulfinyl Analogues of Coenzyme NADH Models[J].中国化学,2007,25(6):839-842. |
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| 作者姓名： | 谢昆 崔毅 刘有成 傅尧 |
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| 作者单位： | [1]Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China [2]College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China （No. 20072036） and the Specialized Research Fund for the Doctoral Program of Higher Education of China.Acknowledgment We would like to thank Professor Yun-Dong Wu of the Hong Kong University of Science and Technology and Peking University for helpful advice. |
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| 摘 要： | An efficient method for the selective hydrogenation of a series of α,β-epoxyketones to β-hydroxyketones using catalytic amount of two sulfinyl analogues of NAD^＋ model compounds is reported. The lack of any diastereoselectivity for the formation of β-hydroxyketones with optically pure sulfinyl analogue of NAD^＋ model supports the radical mechanism proposed previously.
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| 关 键 词： | α β-环氧酮 催化氢化 β-羟基酮 生成 亚砜类似物 辅酶NADH模型 |
| 修稿时间： | 2006-08-292007-02-19 |
Catalytic Hydrogenation of α,β‐Epoxyketones to β‐Hydroxy‐ ketones with Two Sulfinyl Analogues of Coenzyme NADH Models |
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| XlE, Kun CUI, Yi LIU, You-Cheng FU, Yao.Catalytic Hydrogenation of α,β‐Epoxyketones to β‐Hydroxy‐ ketones with Two Sulfinyl Analogues of Coenzyme NADH Models[J].Chinese Journal of Chemistry,2007,25(6):839-842. |
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| Authors: | XlE Kun CUI Yi LIU You-Cheng FU Yao |
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| Institution: | a Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China; b College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, China |
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| Abstract: | An efficient method for the selective hydrogenation of a series of α,β‐epoxyketones to β‐hydroxyketones using catalytic amount of two sulfinyl analogues of NAD+ model compounds is reported. The lack of any diastereoselectivity for the formation of β‐hydroxyketones with optically pure sulfinyl analogue of NAD+ model supports the radical mechanism proposed previously. |
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| Keywords: | Coenzyme NADH model catalytic hydrogenation α β‐epoxyketones |
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