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Bitriazolyl acyclonucleosides with antiviral activity against tobacco mosaic virus |
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| Authors: | Wei Li Zhijin Fan Qiongyou Wu Ling Peng |
| Institution: | a College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China b Département de Chimie, CNRS UPR 3118, 163, Avenue de Luminy, 13288 Marseille, France c State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China d Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China |
| Abstract: | Bitriazolyl acyclonucleosides were synthesized via the Huisgen reaction and then subjected to ammonolysis. The antiviral activity of these nucleosides against tobacco mosaic virus (TMV) was assessed. Like the previously described bitriazolyl compounds, these new bitriazolyl acyclonucleosides were found to show anti-TMV activity. This suggests that the bitriazolyl moieties are important structural features involved in the antiviral activity of these compounds. |
| Keywords: | Triazole nucleosides Acyclonucleosides Bitriazoly compounds Tobacco mosaic virus Anti-TMV |
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