低并发症医用涂层构建策略研究进展

医用材料的功能性主要通过医用材料表面与生物环境接触而表现出来,需要对医用材料表面进行功能化改性,否则在植入/介入过程中会吸附侵入的细菌引发感染或产生凝血引发血栓等并发症,导致器械服役时间缩短及应用失败。基于上述问题在材料表面调控结构组成、构建功能表面、实现低并发症和生物相容性一直是该领域亟需解决的重要科学问题。目前低并发症医用涂层构建方法主要有表面化学接枝改性、单分子层自组装、层层自组装、多巴胺涂层等,结合本课题组近年来在低并发症医用高分子材料及医疗器械的医用涂层研究成果,简单介绍了国内外医用涂层表面构建的研究进展。

Advances in Construction Strategies of Low-Complication Medical Coatings

The functionality of medical materials is mainly exhibited by the contact between the surface of the medical material and the biological environment. It is necessary to functionalize the surface of the medical material. Otherwise,complications such as bacteria-induced infection and blood clot-induced thrombosis may occur during the implantation/intervention process. This leads to shortened service life and application failure. Based on the above problems,controlling structural composition, constructing functional surfaces, achieving low complications and biocompatibility on the surface of materials have always been important scientific problems that need to be solved in this field. At present, the construction methods of low-complication medical coating mainly include surface chemical graft modification, monolayer self-assembly, layer by layer assembly, dopamine coating, etc. Combined with the research group’s low-complication medical polymer materials and medical treatment in recent years, the research results of medical coatings of instruments have briefly introduced the research progress of the surface construction of medical coatings at home and abroad.